Alex Jones

Support Staff

Contact details

+44 (0)1603 450527
Email: alex.jones@sainsbury-laboratory.ac.uk

Research interests

My role within the Sainsbury Laboratory is to facilitate and support entry level usage of mass spectrometry for the identification of proteins and their post-translational modifications. My post-doctoral experience includes protein purification, several different types of mass spectrometry and two-dimensional gel electrophoresis. 

I have a strong background in plant pathology and brassica research from my previous posts at Imperial College (www.imperial.ac.uk) (Rossiter, Grant and Feys groups) and CEH, Dorset (www.ceh.ac.uk).

Selected Publications

Manzano D., Marquardt S., Jones AME , Bäurle I, Liu F., Dean C., (2009) Altered interactions within FY/AtCPSF complexes required for Arabidopsis FCA-mediated chromatin silencing. PNAS in press

Ntoukakis V, Mucyn TS, Gimenez-Ibanez S, Chapman H, Gutierrez JR, Balmuth AL, Jones AME, and Rathjen JP (2009) Host inhibition of a bacterial virulence effector triggers immunity to infection. Science in press. 

Bush M., Hutchins A., Jones A., Naldrett M., Jarmolowski A., Browning K., Lloyd C., Doonan J., (2009) Selective recruitment of proteins to 5 ' cap complexes during the growth cycle in Arabidopsis. The Plant Journal in press

Jones AME, MacLean D, Studholme DJ, Serna-Sanz A, Andreasson E, Peck SC (2009) Phosphoproteomic analysis of nuclei-enriched fractions from Arabidopsis thaliana. J Proteomics  72 (3), 439-451 PMID:19245862

Huang L., Jones AME, Searle I, Patel K, Vogler H, Hubner NC, Baulcombe DC (2009) An atypical RNA polymerase involved in RNA silencing and heterochromatin formation shares small subunits with RNA polymerase II. Nature Structural & Molecular Biology Jan;16(1):91-3. Epub 2008 Dec 14 PMID: 19079263

Kaffarnik FA, Jones AM, Rathjen JP, Peck SC (2009) Effector proteins of the bacterial pathogen Pseudomonas syringae alter the extracellular proteome of the host plant, Arabidopsis thaliana. Mol Cell Proteomics.2009 Jan;8(1):145-56. Epub 2008 Aug 20 .PMID: 18716313

De Lucia F, Crevillen P, Jones AME, Greb T and Dean C (2008) Dynamic association and distinct Polycomb complex composition define different FLC epigenetic states PNAS Nov 4;105(44):16831-6. Epub 2008 Oct 14 PubMed 18854416

MacLean D, Burrell MA, Studholme DJ and Jones AME (2008) PhosCalc: A tool for evaluating the sites of peptide phosphorylation from Mass Spectrometer data. BMC Research Notes 2008, 1:30.

Traka M, Gasper AV, Melchini A, Bacon JR, Needs PW, Frost V, Chantry A, Jones AME, Ortori CA, Barrett DA, Ball RY, Mills RD & Mithen RF. (2008) Broccoli Consumption Interacts with GSTM1 to Perturb Oncogenic Signalling Pathways in the Prostate PLOS One 3(7):e2568. PMID: 18596959

Whiteman SA, Serazetdinova L, Jones AME, Sanders D, Rathjen J, Peck SC & Maathuis FJM. (2008) Identification of novel proteins and phosphorylation sites in the vacuolar membrane of Arabidopsis thaliana. Proteomics 17:3536-47. PMID: 18686298

Romero-Puertas M. C., Laxa M., Mattè A., Zaninotto F., Finkemeier I., Jones A.M.E, Perazzolli M., Vandelle E., . Dietz K.J, Delledonne M. (2007)'S-nitrosylation of peroxiredoxin II E promotes peroxynitrite-mediated tyrosine nitration.' Plant cell 12:4120-30. PMID: 18165327

Heese A., Hann D.R., Gimenez-Ibanez S., Jones A., He k., Jia Li J., Schroederj.I., Peck S.C., Rathjen J.P.(2007) The receptor-like inase serk3/bak1 is a central regulator of innate immunity in plants. Proc Natl Acad Sci USA. 2007 jul 17;104(29):12217-22 pmid: 17626179

Nühse TS., Bottrill AR, Jones AME, Peck SC (2007) Quantitative phosphoproteomic analysis of plasma membrane proteins reveals regulatory mechanisms of plant innate immune responses. Plant J. 2007 sep;51(5):931-40. pmid: 17651370

Maor R., Jones A., Nuhse T.S., Studholme D.J., Peck S.C. and Shirasu K. (2007) Mudpit analysis of ubiquitinated proteins in plants. Mol Cell Proteomics. 2007 apr;6(4):601-10. pmid: 17272265

Jones A.M.E., Mansfield J. and Grant M. (2007) Considerations on post-translational modification and protein targeting in the arabidopsis defence proteome. Plant Signaling and Behavior; 2(3), pp tbc [addendum]

Jones A.M.E., Thomas V., Bennett M.H., Mansfield J. and Grant M. (2006) Modification of host proteins during arabidopsis defence response occurs prior to significant transcriptional change. Plant Physiology; 142, 1603-1620

Jones A.M.E., Bennett M.H., Mansfield J.W. and Grant M. (2006) Analysis of the defence phosphoproteome of arabidopsis thaliana using differential mass tagging. Proteomics; 6 (14) 4155-4165